Top 30 Sinus Medicine on Amazon (Verified You can Buy)
Top 1
PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50
PhysiciansCare
90087
5.12 x 4.6 x 3.37 Inches
0.12 pounds
Ratings for PhysiciansCare (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| SML Shop NY | - | ✅ | ✅ | ✅ |
| GD PLUS | - | ✅ | ✅ | ✅ |
| Midsie | 2,028 | ✅ | ✅ | ✅ |
| Office Depot OfficeMax | 1,221 | ✅ | ✅ | ✅ |
| BIGFLY | 17 | ❌ | ❌ | ❌ |
Features
Compare to the active ingredients in Sudafed PE
Coated, easy-to-swallow tablets.
Top 2
Best Allergy, Sinus & Asthma Medicine
Best for Vicks
Best for Capsule
Best for Headache Relief
Best for Nasal Relief
Best for Liquid
Best for Fever
Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
Vicks
233331
1.1 x 3.313 x 4.313 inches
0.1 pounds
Ratings for Vicks (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Redbud Home | - | ✅ | ✅ | ✅ |
| westlake | 1,900 | ✅ | ✅ | ✅ |
| The Customer Land | - | ✅ | ✅ | ✅ |
| Gustotrade | 4,389 | ✅ | ✅ | ✅ |
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, sinus pain, chest congestion and mucus!
Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it thins and loosens mucus, reduces pressure in the sinuses, and relieves sinus pain!
Top 3
Best OTC Medications & Treatments
Best for Kosher
Best for Headache Relief
Best for Nasal Relief
Best for Liquid
Best for Child
Best for Fever
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets
Advil
305730199216
4.5 x 4.0 x 4.5 inches
Ratings for Advil (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
One package of 20 coated tablets of Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl
Advil ibuprofen 200mg pain medicine for adults temporarily relieves fever, minor body aches and headache
Top 4
Best Allergy, Sinus & Asthma Medicine
Best for Tylenol
Best for Caplet
Best for Capsule
Best for Kosher
Best for Allergy Control
Best for Headache Relief
Best for Nasal Relief
Best for Sinus Control
Best for Liquid
Best for Child
Best for Fever
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
Tylenol
JJ-2320
4.5 x 0.75 x 3.0 inches
0.07 pounds
Ratings for Tylenol (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
Pain reliever and nasal decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure
Top 5
Best Allergy, Sinus & Asthma Medicine
Best for Kosher
Best for Allergy Control
Best for Headache Relief
Best for Nasal Relief
Best for Sinus Control
Best for Liquid
Best for Child
Best for Fever
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, Acetaminophen, Pain Reliever, Fever Reducer, Phenylephrine HCl, Decongestant, Sinus Congestion Relief; 24 ct; Pack of 1
Sudafed
300450547248
0.63 x 2.91 x 4.52 inches
0.0397 pounds
Ratings for Sudafed (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
DECONGESTANT & PAIN RELIEF: Sudafed PE Sinus Pressure and Pain is a maximum strength non-drowsy decongestant tablet for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion.
NON-DROWSY ALLERGY MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold; a nasal decongestant that provides non-drowsy symptom relief.
Sudafed PE Day and Night Sinus Pressure & Congestion Tablets, 20 Count
Sudafed
503835
0.64 x 4.56 x 2.88 inches
0.04 Pounds
Ratings for Sudafed (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
Top 7
Best for Tylenol
Best for Caplet
Best for Headache Relief
Best for Nasal Relief
Best for Sinus Control
Best for Liquid
Best for Child
Best for Fever
Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
Tylenol
JJ-2308
0.789 x 4.524 x 2.914 Inches
0.0063 Pounds
Ratings for Tylenol (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| ISKOLIVE 12 INC | 2,114 | ✅ | ✅ | ✅ |
| American Direct Wholesale | 128 | ✅ | ✅ | ✅ |
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
24-count of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies
Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure
Vicks Personal Sinus Steam Inhaler with Soft Face Mask – Face Humidifier with Targeted Steam Relief Aids with Sinus Problems, Congestion and Cough
Vicks
VIH200
5.16 x 5.16 x 8.58 inches
1.2 Pounds
Ratings for Vicks (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
| Amazon Resale | - | ❌ | ❌ | ❌ |
Features
PERSONAL STEAM INHALER – Vicks Personal Sinus Steam Inhaler provides a warm mist of steam for temporary symptomatic relief from cough, congestion and allergies in a 5-15 minute treatment. Compatible with soothing menthol Vicks VapoPads for added comfort.
QUICK AND EASY TO USE – Get fast relief in a quick 5-15 treatment. With this Vicks steam inhaler, no filters are required and it’s designed to work with tap water.
Sudafed PE Head Congestion + Pain Relief Caplets Ibuprofen Phenylephrine HCl, 20 Count
Sudafed
1.0 x 3.0 x 4.38 inches
0.05 pounds
Ratings for Sudafed (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
20-count of Sudafed PE Non-Drowsy Head Congestion + Pain Relief Caplets for effective nasal congestion relief and nasal swelling relief, now coupled with the powerful pain relief of ibuprofen
From the #1 pharmacist recommended brand among oral OTC decongestants, it provides non-drowsy relief from head congestion and pain symptoms caused by head colds
Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 120 Count
Boiron
3.9 x 3.0 x 2.4 inches
0.1102 pounds
Ratings for Boiron (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
| FINEST-PRODUCTS | - | ❌ | ❌ | ❌ |
Features
SinusCalm tablets relieves nasal congestion, sinus pain and pressure, and headache due to the common cold or allergies.
The non-drowsy, quick-dissolving tablets are phenylephrine-free and won’t interact with other medications. Free from preservatives and artificial colors & flavors.
Top 11
Best for Vicks
Best for Capsule
Best for Kosher
Best for Headache Relief
Best for Nasal Relief
Best for Liquid
Best for Child
Best for Fever
Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps
Vicks
4.4 x 1.1 x 3.3 inches
0.09 Pounds
Ratings for Vicks (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| RMS PRODUCTS Free & Fast Delivery | - | ✅ | ✅ | ✅ |
| Amazon.com | - | ✅ | ✅ | ✅ |
| The Customer Land | - | ✅ | ✅ | ✅ |
Features
Experience fast; powerful relief from nasal congestion; sinus pressure; sinus headache; and sinus pain!
Best suited to treat sinus symptoms caused by the common cold; hay fever; or other upper respiratory allergies because it reduces pressure in the sinuses and relieves sinus pain!
Top 12
Best for Capsule
Best for Gel
Best for Headache Relief
Best for Nasal Relief
Best for Liquid
Best for Fever
AXIV Sinus Severe + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Ease, 24 Softgels.
AXIV
4.3 x 3.3 x 1.2 inches
0.1477 pounds
Ratings for AXIV (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Vivunt Pharma LLC | - | ❌ | ❌ | ❌ |
Features
HSA and FSA eligible product.
Powerful Relief: Experience fast and potent relief from nasal congestion, sinus pressure, sinus pain, sinus headaches, mucus, and chest congestion. Take only as directed, do not exceed 8 LiquiCaps per 24 hrs. Adults & children 12 yrs & over 2: LiquiCaps with water every 4 hrs. Children 4 to under 12 yrs: ask a doctor. Children under 4 yrs: do not use.
Top 13
Best for Homeopathic
Best for Headache Relief
Best for Nasal Relief
Best for Child
Best for Fever
Hyland's Naturals Kids Stuffy Nose & Sinus Tablets, Cold & Allergy Medicine for Children Ages 2+, Headache Relief & Nasal Decongestant, Quick Dissolving Tablets, 50 Count
Hyland's
1.38 x 2.75 x 4.0 inches
0.05 pounds
Ratings for Hyland's (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| BluebirdSales | - | ✅ | ✅ | ✅ |
| Brand Supply Distributors | - | ✅ | ✅ | ✅ |
| Amazon.com | - | ✅ | ✅ | ✅ |
Features
Temporarily relieves symptoms of stuffy nose and sinus in children including: nasal congestion, sinus pressure, and headache
Hyland's Naturals Kids medicines are made with natural active ingredients, and created especially for kids ages 2 to 12
GenCare Nasal Decongestant 10mg Tablets Phenylephrine HCl 300 Tablets Per Bottle Value Pack Non Drowsy Sinus and Nasal Congestion Relief Lower Sinus Pressure Due to Allergies or Illness
GenCare
1.84 x 1.84 x 3.42 inches
Ratings for GenCare (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| GenCare | 5,243 | ✅ | ✅ | ✅ |
| GenCare Consumer Products, LLC | 8,222 | ❌ | ❌ | ❌ |
Features
✅ ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
✅ BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
Tylenol Sinus Severe Daytime Caplets for Pain & Congestion Relief, 50 Travel Packs of 2 ct
Tylenol
30036801
3.29 x 4.42 x 5.76 Inches
0.31 Pounds
Ratings for Tylenol (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
| Arzuq Grocers and More | 1,681 | ✅ | ✅ | ✅ |
Features
50 travel packs of 2-ct. of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies, ideal for both at home and on-the-go
Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure
Top 16
Best for Fever
HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Maximum Strength | Nasal & Sinus Congestion Relief Due to Cold & Allergies (90 Count (Pack of 1))
HealthA2Z
0.0705 pounds
Ratings for HealthA2Z (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| HealthA2Z | 793 | ❌ | ❌ | ❌ |
Features
HealthA2Z Decongestant PE is a Nasal decongestant Phenylephrine HCl 10mg in each tablet (Active Ingredient)
HealthA2Z Decongestant PE Temporarily relieves sinus congestion and pressure
Top 17
Best for Caplet
Best for Headache Relief
Best for Nasal Relief
Best for Liquid
Best for Fever
Sudafed PE Head Congestion Plus Mucus Relief Tablets for Sinus Pressure, Congestion and Headache, Non-Drowsy Decongestant with Acetaminophen, Guaifenesin, Phenylephrine HCI, 24 ct
Sudafed
300450580269
0.75 x 4.44 x 2.88 inches
0.0 Pounds
Ratings for Sudafed (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ❌ | ❌ | ❌ |
Features
24-count box of Sudafed PE: Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus
Sinus medicine contains: 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction; also 200 mg of guaifenesin, an expectorant for mucus reduction
Advil Respiratory Sinus Congestion and Pain Relief Medicine & Fever Reducer with Ibuprofen and Phenylephrine HCl, 50 Count
Advil
305730199018
5.6 x 3.5 x 0.004 inches
5.6 pounds
Ratings for Advil (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
| MyOfficeInnovations/Staples, Inc. | 127 | ✅ | ✅ | ✅ |
| greenBulk | 3,448 | ✅ | ✅ | ✅ |
| AHSR Products | - | ❌ | ❌ | ❌ |
Features
One package of 50 coated tablets of Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl
Advil ibuprofen 200mg pain medicine for adults temporarily relieves fever, minor body aches and headache
Boiron SinusCalm Tabs - 100 Count for Sinus Pressure and Pain Relief, Runny Nose, Congestion, Headache - Sinus Calm Meltaway Tablets
Boiron
43974819938519
0.1169 pounds
Ratings for Boiron (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Peak10 Health LLC | 1,606 | ❌ | ❌ | ❌ |
Features
TARGET SINUS PAIN & CONGESTION: SinusCalm is your solution for seasonal sinus pain relief. It works with your body to relieve nasal congestion, sinus pressure and pain, and sinus headaches
NON-DROWSY MELTAWAY TABLETS: Stay active and alert while finding relief from sinus pain and pressure. These non-drowsy meltaway tablets are easy to take and melt in the mouth without water, chewing, or swallowing.
Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Sinus Pressure Relief, Cold and Allergy Medicine, Decongestant, 1 fl oz (Pack of 1)
Amazon Basic Care
1.313 x 2.125 x 4.875 Inches
Ratings for Amazon Basic Care (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ❌ | ❌ | ❌ |
Features
ACTIVE INGREDIENT: This nasal spray contains oxymetazoline hydrochloride 0.05%, a nasal decongestant. Compare to the active ingredient in Afrin Original.
PURPOSE: This nasal spray temporarily relieves nasal congestion, sinus congestion and pressure due to the common cold, hay fever and upper respiratory allergies.
Boiron SinusCalm Allergy Tablets for Relief from Sinus Pressure, Sinus Headache, or Sinus Congestion and Pain - 60 Count
Boiron
306969339046
3.95 x 3.05 x 1.2 inches
0.0661 pounds
Ratings for Boiron (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ❌ | ❌ | ❌ |
Features
TARGET SINUS PAIN & CONGESTION: SinusCalm Allergy by Boiron is your solution for seasonal sinus pain relief. It works with your body to relieve nasal congestion, sinus pressure and pain, and sinus headaches triggered by allergies.* Suitable for ages 6 and up.
NON-DROWSY MELTAWAY TABLETS: Stay active and alert while finding relief from sinus pain and pressure. These non-drowsy meltaway tablets are easy to take and melt in the mouth without water, chewing, or swallowing.
FamilyCare Nasal Relief Spray, Pump Mist, Anti-drip, Severe Congestion, (Oxymetazoline HCI) 12 Hours, 3 Pack
Family Care
1.0 x 0.6 x 3.0 inches
0.24 pounds
Ratings for Family Care (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Useful Universe | 2,468 | ✅ | ✅ | ✅ |
| Vital Lakes Store | - | ✅ | ✅ | ✅ |
| WeRespectMAP | - | ✅ | ✅ | ✅ |
| WISECARE | - | ❌ | ❌ | ❌ |
| Kaizen8 | 571 | ❌ | ❌ | ❌ |
| GVJ Goods | - | ❌ | ❌ | ❌ |
Features
12 hour nasal relief
severe congestion
Top 23
Best for Liquid
HealthA2Z Cold & Allergy Relief, Chlorpheniramine Maleate & Phenylephrine HCL, Dye Free, 24 Tablets x 3pack (72 Tablets)
HealthA2Z
0.0705 pounds
Ratings for HealthA2Z (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| HealthA2Z | 793 | ❌ | ❌ | ❌ |
Features
HealthA2Z Cold & Allergy tablets offer temporary relief from sinus pressure and congestion, sneezing, itchy, watery eyes, and runny nose, calms hay fever or other respiratory allergies.
HealthA2Z Cold & Allergy can relieve both indoor and outdoor allergy symptoms.
ValuMeds Nasal Decongestant PE Non-Drowsy for Adults | Maximum Strength Phenylephrine HCl 10mg to Relieve Sinus Pressure from Cold or Allergies | Comparable to Sudafed PE Congestion | 100 Tablets
ValuMeds
1.0 x 1.0 x 3.0 inches
Ratings for ValuMeds (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Next Generation Health | 1,929 | ❌ | ❌ | ❌ |
Features
MAXIMUM STRENGTH NON-DROWSY CONGESTION RELIEF: Formulated with Phenylephrine HCl 10 mg, this adult nasal decongestant provides powerful, non-drowsy relief from sinus pressure, nasal congestion, and stuffy nose caused by the common cold, hay fever, seasonal allergies, and indoor allergens, helping you breathe easier and stay alert during the day.
EFFECTIVE ORAL DECONGESTANT FOR COLDS & ALLERGIES: Works by shrinking swollen nasal passages to restore airflow and reduce pressure in the sinuses, making it an ideal cold medicine and allergy relief tablet for congestion, sinus headaches, and nasal blockage without the use of antihistamines.
Top 25
Best Allergy, Sinus & Asthma Medicine
Best for Allergy Control
Best for Headache Relief
Best for Nasal Relief
Best for Sinus Control
Best for Child
Best for Fever
HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count (Pack of 1))
HealthA2Z
0.14 pounds
Ratings for HealthA2Z (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| HealthA2Z | 793 | ❌ | ❌ | ❌ |
Features
🔴 Powerful Nasal Decongestant: Each tablet contains Phenylephrine HCl 10 mg, an effective nasal decongestant that provides temporary relief from nasal and sinus congestion due to colds, hay fever, or upper respiratory allergies.
🔴 Great Value Supply: Includes 300 tablets per bottle — a long-lasting supply ideal for home, office, or travel medicine cabinets.
Top 26
Best for Liquids
Best for Allergy Control
Best for Headache Relief
Best for Nasal Relief
Best for Sinus Control
Best for Spray
Best for Liquid
Best for Child
AXIV Sinus Head Congestion Relief, Non-Drowsy, Maximum Strength for Sinus Pressure, Headache, Pain & Stuffy Nose, 24 Softgels
AXIV
4.6 x 3.3 x 1.2 Inches
0.0075 pounds
Ratings for AXIV (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Vivunt Pharma LLC | - | ❌ | ❌ | ❌ |
Features
Powerful Relief: Provides fast and effective relief from sinus pressure, sinus headaches, nasal congestion, and stuffy nose. Adults and children 12 years & over: take 2 softgels with water every 4 hours as needed. Do not exceed 8 softgels in 24 hours. Children under 12 years: ask a doctor.
Effective Formula: Combines a trusted pain reliever (Acetaminophen) and a nasal decongestant (Phenylephrine HCl) to reduce sinus pressure, relieve headache pain, and clear nasal passages for easier breathing.
Top 27
Best for Drops
Best for Liquids
Best for Gluten-Free
Best for Nasal Relief
Best for Soothing
Best for Spray
Best for Liquid
Best for Fever
Amazon Basic Care No Drip Nasal Spray, 12 Hour Maximum Strength Nasal Decongestant, Oxymetazoline HCl, Fast-Acting Sinus Pressure Relief, 1 fl oz (Pack of 1)
Amazon Basics
B07MLTLN75
1.31 x 1.94 x 4.88 inches
0.13 Pounds
Ratings for Amazon Basics (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ❌ | ❌ | ❌ |
Features
ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, the #1 doctor recommended adult nasal spray active ingredient (of U.S. physicians surveyed by an independent market research firm). Compare to the active ingredient in Afrin No Drip.
SOOTHING 12 HOUR MAXIMUM STRENGTH RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies.
ValuMeds Nasal Decongestant PE Phenylephrine HCl 10mg Tablets (Bulk 300 Count) Non-Drowsy Sinus Pressure Relief & Nasal Congestion Relief, Stuffy Nose Decongestants for Adults | Compare to Sudafed PE
ValuMeds
0.1301 Pounds
Ratings for ValuMeds (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Next Generation Health | 1,929 | ❌ | ❌ | ❌ |
Features
MAXIMUM STRENGTH NON-DROWSY CONGESTION RELIEF: Formulated with Phenylephrine HCl 10 mg, this adult nasal decongestant provides powerful, non-drowsy relief from sinus pressure, nasal congestion, and stuffy nose caused by the common cold, hay fever, seasonal allergies, and indoor allergens, helping you breathe easier and stay alert during the day.
EFFECTIVE ORAL DECONGESTANT FOR COLDS & ALLERGIES: Works by shrinking swollen nasal passages to restore airflow and reduce pressure in the sinuses, making it an ideal cold medicine and allergy relief tablet for congestion, sinus headaches, and nasal blockage without the use of antihistamines.
Top 29
Best OTC Medications & Treatments
Best Nasal Sprays
Best Moisturizing Nasal Sprays
Best for Sprays
Best for Sprays
Best for Vicks
Best for Headache Relief
Best for Nasal Relief
Best for Spray
Best for Liquid
Best for Child
Best for Allergy
Best Over-the-Counter Medication
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief From Stuffy Nose due To Cold Or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2
Vicks
bergw-306
2.56 x 3.86 x 5.4 Inches
0.0625 Pounds
Ratings for Vicks (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ✅ | ✅ | ✅ |
| Whole Premium Store | - | ✅ | ✅ | ✅ |
Features
Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
Breathe better all day or all night long with Vicks Sinex Severe; For instant; 12-hour; nasal congestion and sinus pressure relief
Top 30
Best for Mucinex
Best for Liquids
Best for Headache Relief
Best for Nasal Relief
Best for Liquid
Mucinex Maximum Strength Sinus-Max Severe Congestion & Pain + Nightshift Sinus Liquid, Cold and Flu Medicine for Adults, Over-the-Counter Medication for Multi-Symptom Relief, 2x6 Fl Oz
Mucinex
6382451067
1.43 x 2.52 x 5.71 inches
0.0344 pounds
Ratings for Mucinex (CPR Score)
| Seller | CPR Rank | Amazon Fulfilled | Prime | Free Shipping |
|---|---|---|---|---|
| Amazon.com | - | ❌ | ❌ | ❌ |
Features
POWERFUL MULTI-SYMPTOM RELIEF: This combo pack of Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain and Mucinex Nightshift Sinus provides powerful multi-symptom relief for your worst sinus congestion symptoms
SEVERE CONGESTION & PAIN SYMPTOM RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve headache, sinus congestion and thin & loosen mucus
Top 10 Sinus Medicine - Verified to Buy (October 2026)
- 1. PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box...
- 2. Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens...
- 3. Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever...
- 4. Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg,...
- 5. Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength,...
- 6. Sudafed PE Day and Night Sinus Pressure & Congestion Tablets,...
- 7. Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine...
- 8. Vicks Personal Sinus Steam Inhaler with Soft Face Mask – Face Humidifier with Targeted...
- 9. Sudafed PE Head Congestion + Pain Relief Caplets Ibuprofen Phenylephrine...
- 10. Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion,...
Top 10 Sinus Medicine Brands on Amazon
Here is the list of top-rated brands that were evaluated by CherryPicks.
- PhysiciansCare
- Vicks
- Advil
- Tylenol
- Sudafed
- Boiron
- AXIV
- Hyland's
- GenCare
- HealthA2Z
Specific Sinus Medicine Guides
For more personalized Sinus Medicine guides to match your different needs, check out the following pages,
Attribute
Top 10 Sinus Medicine Sellers: CPR Seller Rank List
CPR sellers rank is based on CherryPicks-AI bestselling ranking system that helps us analyze each seller's sales trends. The List of top seller ranks is our in-house data, essential for our product ranking to help you make the right shopping choice.
- 1. BIGFLY : 758,848 Yearly Feedback , Avg. Ratings 4.9
- 2. MyOfficeInnovations/Staples, Inc. : 240,793 Yearly Feedback , Avg. Ratings 4.6
- 3. American Direct Wholesale : 240,296 Yearly Feedback , Avg. Ratings 4.8
- 4. Kaizen8 : 76,832 Yearly Feedback , Avg. Ratings 4.9
- 5. HealthA2Z : 59,638 Yearly Feedback , Avg. Ratings 4.9
- 6. Office Depot OfficeMax : 42,883 Yearly Feedback , Avg. Ratings 4.4
- 7. Peak10 Health LLC : 34,889 Yearly Feedback , Avg. Ratings 4.9
- 8. Arzuq Grocers and More : 33,721 Yearly Feedback , Avg. Ratings 4.8
- 9. westlake : 30,379 Yearly Feedback , Avg. Ratings 4.8
- 10. Next Generation Health : 30,090 Yearly Feedback , Avg. Ratings 4.8
| Rank | Name | Yearly Feedbacks | Avg. Ratings |
|---|---|---|---|
| 🥇 | BIGFLY | 758,848 | 4.9 |
| 🥈 | MyOfficeInnovations/Staples, Inc. | 240,793 | 4.6 |
| 🥉 | American Direct Wholesale | 240,296 | 4.8 |
| 4 | Kaizen8 | 76,832 | 4.9 |
| 5 | HealthA2Z | 59,638 | 4.9 |
| 6 | Office Depot OfficeMax | 42,883 | 4.4 |
| 7 | Peak10 Health LLC | 34,889 | 4.9 |
| 8 | Arzuq Grocers and More | 33,721 | 4.8 |
| 9 | westlake | 30,379 | 4.8 |
| 10 | Next Generation Health | 30,090 | 4.8 |
[Get] Sinus Medicine Deals (✅Exclusively for Prime)
What does "Amazon Fulfilled" Mean?
Amazon Fulfilled refers to products handled by Amazon's logistics, which indicates that the product is stored, packed, and shipped by Amazon from one of its fulfillment centers.
When you order a product that is "Amazon Fulfilled," Amazon takes care of the storage, packing, shipping, and customer service for that product. This often ensures quicker delivery and better customer service compared to products that are not fulfilled by Amazon. It also means that the product is eligible for Amazon's return policy.
What does "Prime" Mean?
"Prime" refers to Amazon Prime Member (Join Amazon Prime Now), which indicates eligibility for Prime benefits. When you see "Prime" next to a product on Amazon, This generally means that if you are an Amazon Prime member, you can get free two-day shipping on that product, and sometimes even same-day or one-day shipping depending on your location.
Prime members also have access to other benefits, including 2-Day Shipping, Exclusive Member Deals, Prime Video, Buy With Prime, Amazon Music, Prime Gaming, and more.
Shop Prime Sinus Medicine Deals
What does "Free Shipping" Mean?
"Free Shipping" means that you will not be charged additional fees for the shipping of that product. However, unlike "Prime," which usually guarantees fast two-day shipping, "Free Shipping" doesn't necessarily mean fast shipping.
Sometimes there might be a minimum purchase requirement to qualify for free shipping if you are not a Prime member. For Prime members, the "Free Shipping" usually refers to the free two-day shipping that is one of the benefits of the Prime membership.
Why Should You Trust Us?
Now hundreds and thousands of Health Care supplies are available on Amazon, Picking the right one is not easy, and that may take a lot of your time, Right? and What is the best Sinus Medicine to buy for new October 2026?
CherryPicks’s Methodology for Evaluating Sinus Medicine
We developed the CherryRatings-AI system to identify and score reviews and the CherryPicks-AI ranking system that uses TensorFlow framework to generate the best list, It will help us evaluate Health Care items that sell on Amazon. The score of items is based on over ten parameters such as analyzing customer review content, product reviewing rating statistics, brand reputation evaluation, comparing product price with features, etc, You can visit How We Rank to learn more in detail.
We collected and analyzed 306 of Sinus Medicine reviews based on our selection criteria. It helped us shortlist the top qualified and rated Sinus Medicine for Health Care, We found that most customers choose Sinus Medicine with an average price of $13.42, and the top brands are Amazon Basics, Amazon Basic Care, Vicks, Tylenol, Boiron, Hyland's, Mucinex, HealthA2Z, Advil, ValuMeds, Sudafed And PhysiciansCare.
Then our expert-level editors reviewed all those quality items and selected the top 30 Sinus Medicine for you, We have researched hundreds of sellers and picked the top sellers for Health Care, including Amazon Resale, BIGFLY, MyOfficeInnovations/Staples, Inc., American Direct Wholesale, Kaizen8, HealthA2Z, Office Depot OfficeMax, Peak10 Health LLC, Arzuq Grocers and More, westlake, Next Generation Health And Midsie. The PhysiciansCare Sinus Decongestant Congestion Me... are available for purchase right now, and The seller of #1 rank product has received honest feedback from 199 consumers with an average rating of 4.6.
We've helped a lot of satisfied users get the right Health & Household product based on their needs, and save lots of time for them to pick Sinus Medicine to buy.
Rebecca's favorite quote is "health is wealth," and being healthy comes with its own challenges, especially for those without a background in health sciences. With the help of Rebecca Emi, you will discover the products to use and the ones not to use.